So what is it? As the name suggests, it is chemotherapy that has been heated to 42-43 degrees Celsius. It is given while in the OR immediately following cytoreductive surgery and is administered over approximately a 90 minute period. During that time, surgeons vigorously palpate the abdomen to ensure that the chemo is well spread throughout. It is heated because heated chemo has been shown to be better absorbed by the tissue. Given that the dose of chemo can be increased because it is not given through IV, there are very few side effects. The aim is to destroy remaining cancer cells that are too small to see.
There is an excellent article about the use of HIPEC published in 2020. You can read that article by following this link.